How long should Depakote be taken? How should I take Valproate? Valproate is usually is taken 1-3 times daily. It may be taken with or without food. Typically patients begin at a low dose of medicine and the dose is increased slowly over several weeks. Can you stop Depakote cold turkey? Before quitting Depakote " cold turkey ", seek competent medical advice. The usual procedure would not be to abruptly stop the medication, but to seek help in slowly tapering off the medication. Always speak to your doctor before deciding to stop Depakote. What does Depakote do to the brain? How does Depakote work? It is a combination of valproic acid and sodium valproate. Valproate semisodium works by increasing the amount of a natural 'nerve-calming' chemical in the brain, called GABA. This helps to calm periods of mania and stabilise mood. Can valproic acid damage brain? Background. Hyperammonemia is known to cause neuronal injury, and can result from valproic acid exposure. Prompt reduction of elevated ammonia levels may prevent permanent neurological injury. We report a case of fatal hyperammonemic brain injury in a woman exposed to valproic acid. Is divalproex a narcotic? Divalproex sodium is sometimes used together with other seizure medications. Divalproex sodium is also used to treat manic episodes related to bipolar disorder (manic depression), and to prevent migraine headaches. Divalproex sodium may also be used for purposes not listed in this medication guide.
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