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Are topical medications absorbed systemically? Topical drugs, the mainstay of treatment in dermatology, are applied in the hope and expectation that any percutaneous absorption will be minimal and that systemic side effects will not occur. Undoubtedly, drugs can be absorbed through the skin and produce either unwanted or intended systemic effects. What causes loss of skin elasticity? The loss of the elastic tissue (elastin) in the skin with age causes the skin to hang loosely. Skin becomes more transparent. This is caused by thinning of the epidermis (surface layer of the skin). Skin becomes more fragile.
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