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Can I take Claritin and Benadryl at the same time? However, patients should not take Benadryl and Claritin together without doctor advice. They are both antihistamines and work similarly in the body, also Claritin is long-acting drug, so if they are taken together their effects will overlap and patients may duplicate the active drug of each medication. How do you treat non allergic rhinitis naturally? Treatment Saline nasal sprays. Use an over-the-counter nasal saline spray or homemade saltwater solution to flush the nose of irritants and help thin the mucus and soothe the membranes in your nose. Corticosteroid nasal sprays. Antihistamine nasal sprays. Anti-drip anticholinergic nasal sprays. Decongestants.
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